A Vitamin for Autophagy

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• 作者：Mario Fabri ; Robert L. Modlin
• 刊名：Cell Host Microbe
• 出版年：2009
• 出版时间：17 September 2009
• 年：2009
• 卷：6
• 期：3
• 页码：201-203
• 全文大小：328 K

文摘

Recent discoveries have revealed the importance of the vitamin D-dependent generation of antimicrobial peptides in human host defense against Mycobacterium tuberculosis. Now, Yuk et al. (2009) show how vitamin D induces autophagy and mediates colocalization of Mycobacterium tuberculosis and antimicrobial peptides within an autophagolysosome, leading to killing of the bacterium.