Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo
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- 作者：Cé ; lia Jeronimo1 ; Marie-France Langelier2 ; Alain R. Bataille3 ; John M. Pascal2 ; B. Franklin Pugh3 ; Franç ; ois Robert1 ; 4 ; 5 ; francois.robert@ircm.qc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：mediator ; kinase module ; tail module ; Cdk8/Srb10 ; TFIIH/Kin28
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：64
- 期：3
- 页码：455-466
- 全文大小：3536 K
文摘
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A dynamic model for Mediator module interactions with genes
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CKM is release upon integration of Mediator into the pre-initiation complex
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Mediator can integrate the PIC without prior recruitment to UAS by the Tail module
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CKM regulates Mediator-UAS interactions rather than Mediator-PIC association