Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome
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- 作者：Debora Fumagalli1 ; 10 ; David Gacquer2 ; 10 ; Franç ; oise Rothé ; 1 ; 10 ; Anne Lefort2 ; Frederick Libert2 ; David Brown1 ; Naima Kheddoumi1 ; Adam Shlien4 ; Tomasz Konopka2 ; Roberto Salgado1 ; Denis Larsimont5 ; Kornelia Polyak6 ; Karen Willard-Gallo7 ; Christine Desmedt1 ; Martine Piccart8 ; Marc Abramowicz9 ; Peter J. Campbell4 ; Christos Sotiriou1 ; 8 ; 11 ; christos.sotiriou@bordet.be" class="auth_mail" title="E-mail the corresponding author ; Vincent Detours2 ; 3 ; 11 ; vdetours@ulb.ac.be" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：13 October 2015
- 年：2015
- 卷：13
- 期：2
- 页码：277-289
- 全文大小：3479 K
文摘
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A-to-I editing is a major source of mRNA variability in breast and other cancers
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RNA editing is globally controlled by tumor interferon and ADAR copy number
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Both these factors are highly prevalent among human cancers
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RNA editing sites might represent a new class of therapeutic targets