A pilot study showing associations between frequency of CD4+ memory cell subsets at diagnosis and duration of partial remission in type 1 diabetes
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- 作者：Rosita Moyaa ; rmoya@sdbri.org" class="auth_mail" title="E-mail the corresponding author ; Hannah Kathryn Robertsona ; hrobertson93@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Dawson Paynea ; dpayne@ucsd.edu" class="auth_mail" title="E-mail the corresponding author ; Aditi Narsalea ; anarsale@sdbri.org" class="auth_mail" title="E-mail the corresponding author ; Jim Koziolb ; koziol@scripps.edu" class="auth_mail" title="E-mail the corresponding author ; the Type 1 Diabetes TrialNet Study Group
- 关键词：T1D ; type 1 diabetes ; BGL ; blood glucose level ; HbA1c ; glycosylated hemoglobin ; IDAA1c ; insulin dose adjusted A1c ; Treg ; Foxp3+ regulatory T cell ; PBMC ; peripheral blood mononuclear cells ; IRB ; Institutional Review Board ; mAb ; monoclonal antibody ; AUC ; area under the curve ; HA ; hyaluronan ; MFI ; mean fluorescence intensity ; CM ; central memory ; TM ; transitional memory ; EM ; effector memory ; EMRA ; CD45RA+ effector memory
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：166-167
- 期：Complete
- 页码：72-80
- 全文大小：1148 K
文摘
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Frequency of CD45RO+ memory cell subsets correlates with length of partial remission in T1D.
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CD25+ CD127hi frequency is a strong predictor of remission length when used as a covariate with baseline HbA1c.
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CD25+ CD127hi frequency is a strong predictor of remission length when used as a covariate with baseline C-peptide.
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CD25+ CD127hi cells are neither Foxp3+ Treg nor Tr1 cells.
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Frequency of CD25+ CD127hi cells correlates with the frequency of activated Treg.