Reversine triggers mitotic catastrophe and apoptosis in K562 cells
详细信息 查看全文
- 作者：Ana Paula Nunes Rodrigues Alves ; Joã ; o Agostinho Machado-Neto ; Priscila Santos Scheucher ; Helder Henrique Paiva ; Belinda Pinto Simõ ; es ; Eduardo Magalhã ; es Rego ; Fabiola Traina ; ftraina@fmrp.usp.br" class="auth_mail" title="E-mail the corresponding author ; fabiolatraina@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Reversine ; Chronic myeloid leukemia ; Aurora kinase B ; Cell viability ; Mitotic catastrophe ; Apoptosis
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：26-31
- 全文大小：2213 K
文摘
- •
The identification of novel targets for chronic myeloid leukemia is of interest.
- •
BCR-ABL1 inhibition reduces AURKA and AURKB expression.
- •
Reversine is an AURKA and AURKB inhibitor.
- •
Reversine leads to increased apoptosis and mitotic catastrophe in K562 cells.
- •
Reversine exibits antileukemic activity against K562 cells.