Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways
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- 作者：Hsiao-Yen Hsieha ; b ; c ; Cheng-Huang Shena ; d ; Ru-Inn Line ; Yu-Min Fengf ; i ; Shih-Yuan Huangb ; c ; Yuan-Hung Wangg ; h ; Shu-Fen Wub ; c ; Cheng-Da Hsua ; b ; d ; cdh199712@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Michael W.Y. Chanb ; c ; biowyc@ccu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cyproheptadine ; mTOR signaling ; Wnt/β-catenin signaling ; ANGPTL4 ; Urothelial carcinoma
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：370
- 期：1
- 页码：56-65
- 全文大小：2972 K
文摘
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Cyproheptadine inhibits proliferation and induces apoptosis in urothelial carcinoma cells in vitro and in vivo.
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Cyproheptadine suppresses mTOR through the GSK3β/TSC2/mTOR and GSK3β/β-catenin axes.
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Cells treated with cyproheptadine result in reduction of c-Myc, induction of p21, p27 and stabilization of Rb.
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RNA-Seq found that the effect of cyproheptadine on UC cells may be due to up-regulation of ANGPTL4.