Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats

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• 作者：Fabio Santos Lira^a ; Andrea Maculano Esteves^b ; ^{andrea.esteves@fca.unicamp.br} ; Gustavo Duarte Pimentel^c ; José ; Cesar Rosa^d ; Miriam Kannebley Frank^b ; Melise Oliveira Mariano^e ; Josiane Budni^f ; Joã ; o Quevedo^f ; Ronaldo Vagner dos Santos^g ; Marco Tú ; lio de Mello^h
• 关键词：Sleep ; Locomotor activity ; Doxorubicin ; Rats
• 刊名：Sleep Science
• 出版年：2016
• 出版时间：July-September 2016
• 年：2016
• 卷：9
• 期：3
• 页码：232-235
• 全文大小：467 K
• 卷排序：9

文摘

We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group.MethodsSixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and locomotor activity was evaluated in an open-field test.ResultsIn the light period, the total sleep time and slow wave sleep were decreased, while the wake after sleep onset and arousal were increased in the DOXO group compared with the control group (p<0.05). In the dark period, the total sleep time, arousal, and slow wave sleep were increased, while the wake after sleep onset was decreased in the DOXO group compared with the control group (p<0.05). Moreover, DOXO induced a decrease of crossing and rearing numbers when compared control group (p<0.05).ConclusionsTherefore, our results suggest that doxorubicin induces sleep pattern impairments and reduction of locomotor activity.