Synthesis and free radical scavenging activity of 2-alkyl/arylchalcogenyl-N-(4-aryl-1,3-thiazol-2-yl)acetamide compounds

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• 作者：Lucas Wolf^a ; Natá ; lia Quoos^a ; Joã ; o C.P. Mayer^a ; Diego de Souza^a ; André ; C. Sauer^a ; Luana Meichtry^b ; Vandreza Bortolotto^b ; Marina Prigol^b ; Oscar E.D. Rodrigues^a ; Luciano Dornelles^a ; ^{ldornel@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Heterocyclic ; Thiazole ; Organochalcogen ; Antioxidant effect
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：2 March 2016
• 年：2016
• 卷：57
• 期：9
• 页码：1031-1034
• 全文大小：591 K

文摘

The synthesis of a new series of organochalcogen-derivatives, 2-alkyl/arylchalcogenyl-N-(4-aryl-1,3-thiazol-2-yl)acetamides rong class="boldFont">5arong>–rong class="boldFont">rrong>, provided products in satisfactory yields, which varied from 42% to 95%. All these novel compounds were screened for their in vitro free radical scavenging activity against 2,2-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals. Compounds rong class="boldFont">5rong> (rong class="boldFont">mrong>, rong class="boldFont">hrong>, rong class="boldFont">irong>, rong class="boldFont">frong>, rong class="boldFont">qrong>, rong class="boldFont">grong>, rong class="boldFont">lrong>, rong class="boldFont">crong>, rong class="boldFont">nrong>) were effective scavengers against the ABTS radical species but less effective on scavenging the DPPH radical, indicating that the antioxidant effect of these compounds were related to protonated radical scavenger activity.