A series of Albiziabioside A derivatives substituted with cinnamoyl groups were designed and synthesized.
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The compound rong class="boldFont">8nrong> was found with much less cytotoxicity towards normal cells lines.
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The anti-proliferative activity of rong class="boldFont">8nrong> could be attributed to the induction of cell cycle arrest and apoptosis in HCT116 cells.