Steroidal saponins from the leaves of Cordyline fruticosa (L.) A. Chev. and their cytotoxic and antimicrobial activity

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• 作者：Romuald T. Fouedjou ; R茅my B. Teponno ; Luana Quassinti ; Massimo Bramucci ; Dezemona Petrelli ; Luca A. Vitali ; Dennis Fiorini ; L茅on A. Tapondjou ; Luciano Barboni
• 关键词：Cordyline fruticosa ; Agavaceae ; Steroidal saponins ; Biological activity
• 刊名：Phytochemistry Letters
• 出版年：February, 2014
• 年：2014
• 卷：7
• 期：Complete
• 页码：62-68
• 全文大小：595 K

文摘

Three new steroidal saponins, spirosta-5,25(27)-diene-1尾,3尾-diol-1-O-伪-l-rhamnopyranosyl-(1鈫?)-尾-d-fucopyranoside (fruticoside H) rong class="boldFont">1rong>, 5伪-spirost-25(27)-ene-1尾,3尾-diol-1-O-伪-l-rhamnopyranosyl-(1鈫?)-(4-O-sulfo)-尾-d-fucopyranoside (fruticoside I) rong class="boldFont">2rong>, and (22S)-cholest-5-ene-1尾,3尾,16尾,22-tetrol 1-O-尾-galactopyranosyl-16-O-伪-l-rhamnopyranoside (fruticoside J) rong class="boldFont">3rong>, together with the known quercetin 3-O-尾-d-glucopyranoside, quercetin 3-O-[6-trans-p-coumaroyl]-尾-d-glucopyranoside, quercetin 3-rutinoside, apigenin 8-C-尾-d-glucopyranoside and farrerol, were isolated from the leaves of Cordyline fruticosa. Their structures were elucidated by spectroscopic techniques (¹H NMR, ¹³C NMR, HSQC, ¹H-¹H COSY, HMBC, TOCSY, NOESY), mass spectrometry (HRESIMS, Tandem MS-MS), chemical methods and by comparison with published data. Compounds rong class="boldFont">1rong> and rong class="boldFont">2rong> showed moderate cytotoxic activity against MDA-MB 231 human breast adenocarcinoma cell line, HCT 116 human colon carcinoma cell line, and A375 human malignant melanoma cell line, while compound rong class="boldFont">3rong> was not active. Compound rong class="boldFont">2rong> also showed a moderate antibacterial activity against the Gram-positive Enterococcus faecalis.