Comb-like amphiphilic copolymer mPEG-g-PLL-b-Phe was successfully synthesized.
Polypeptide-based copolymer could self-assemble into multicompartment nanomicelles.
The nanomicelles could co-deliver DOX and P-gp siRNA into MCF-7 cells.
DOX and P-gp siRNA had a synergistic inhibitory effect on cellular proliferation.