Determinants of tyrosylprotein sulfation coding and substrate specificity of tyrosylprotein sulfotransferases in metazoans
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- 作者：Cristina Hartmann-Fatub ; Peter Bayera ; peter.bayer@uni-due.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tyrosylprotein sulfotransferase (TPST) ; 3&prime ; -Phosphoadenosin-5&prime ; -phosphosulfat (PAPS) ; Tyrosine sulfation ; Acidic motif ; trans-Golgi ; Sialyltransferase ; Glycosylation
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 November 2016
- 年：2016
- 卷：259
- 期：part_PA
- 页码：17-22
- 全文大小：484 K
文摘
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Tyrosyl-sulfation is a functional important modification of many secreted proteins.
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Tyrosylprotein sulfotransferases (TPST) catalyze this post-translational modification.
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Human TPSTs are expressed in two isoforms which recognize different substrates.
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The determinants of substrate selection and sulfation coding are barely understood.
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Higher organization levels of TPSTs have recently been discovered in the trans-Golgi.