New look inside human breast ducts with Raman imaging. Raman candidates as diagnostic markers for breast cancer prognosis: Mammaglobin, palmitic acid and sphingomyelin
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- 作者：Halina Abramczyk ; abramczy@mitr.p.lodz.pl" class="auth_mail" title="E-mail the corresponding author ; Beata Brozek-Pluska
- 关键词：Breast cancer markers ; Raman imaging ; Metabolism of lipids
- 刊名：Analytica Chimica Acta
- 出版年：2016
- 出版时间：25 February 2016
- 年：2016
- 卷：909
- 期：Complete
- 页码：91-100
- 全文大小：4408 K
文摘
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Carotenoids, mammaglobin, palmitic acid, sphingomyelin as key molecular targets in ductal breast cancer have been identified.
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The composition of the epithelial cells surrounding the lumen of the cancerous duct changes in comparison with a normal duct.
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In contrast to the normal duct there is a complete depletion of carotenoids in the cancerous duct.
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The cancerous duct contains smaller amount of monounsaturated fatty acids than the normal duct dominated by oleic acid.
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For the cancerous duct a higher level of saturated lipids and sphingomyelin compared to the normal one is observed.