Recombinant polymorphic membrane protein D in combination with a novel, second-generation lipid adjuvant protects against intra-vaginal Chlamydia trachomatis infection in mice
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- 作者：Wayne Paesa ; b ; wayne.paes@ndm.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Naj Browna ; Andrzej M. Brzozowskib ; Rhea Colerc ; Steve Reedc ; Darrick Carterc ; Martin Blandd ; Paul M. Kayea ; Charles J.N. Laceya
- 关键词：Chlamydia trachomatis ; Vaccine ; Pmps ; TLR4 adjuvant
- 刊名：Vaccine
- 出版年：2016
- 出版时间：29 July 2016
- 年：2016
- 卷：34
- 期：35
- 页码：4123-4131
- 全文大小：1248 K
文摘
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rPmpD in combination with SLA elicits significant protection against intra-vaginal Ct challenge.
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Antibodies induced by immunisation with rPmpD recognise Ct elementary bodies.
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SLA is a novel adjuvant class that may be widely used in future preclinical Ct vaccine development.