Various risk factors may interact to precipitate presymptomatic Parkinson’s disease.
We investigated the interaction between α-synuclein and the pesticide, rotenone.
Dual exposure to α-synuclein and rotenone precipitated Parkinsonism in rats.
20">Rats exposed to both factors had profound motor dysfunction and neurodegeneration.
25">This highlights the importance of these interactions in Parkinson’s disease.