Epigallocatechin gallate (eGCG) has inhibitory activity against the ricin toxin (RT).
The reduction in ricin toxicity mediated by eGCG was concentration dependent.
EGCG was found to reduce the binding of RT B chain to lactose-conjugated Sepharose.
EGCG significantly reduces the uptake of RT B chain in Vero cells.
EGCG may provide a starting point to refine substances that reduce ricin toxicity.