Rtt107 BRCT domains act as a targeting module in the DNA damage response
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- 作者：Grace P. Leunga ; Joshua A.R. Browna ; J.N. Mark Gloverb ; Michael S. Kobora ; msk@cmmt.ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rtt107 ; DNA damage response ; BRCT domains ; Saccharomyces cerevisiae
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：37
- 期：Complete
- 页码：22-32
- 全文大小：2751 K
文摘
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Rtt107 BRCT3/4 and 5/6 domains mediated recruitment to double-stranded breaks.
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Rad9 BRCT domains were able to functionally replace Rtt107 BRCT5/6 domains.
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Slx4 but not Dpb11 was dependent on Rtt107 for its recruitment to DNA lesions.
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Fusing Rtt107 BRCT5/6 domains to Slx4 alleviated some phenotypes of rtt107Δ mutants.