In human T cells mifepristone antagonizes glucocorticoid non-genomic rapid responses in terms of Na+/H+-exchange 1 activity, but not ezrin/radixin/moesin phosphorylation
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- 作者：Eileen Jea Chiena ; c ; d ; eileen@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Ching-Hui Hsue ; Vincent Han-Jhih Changa ; Enoch Pin-Yi Lina ; Trista Pin-Tsun Kuoa ; Chau-Heng Chiena ; Hsiao-Yi Linb ; e ; hylin@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mifepristone ; Glucocorticoids ; Ezrin/radixin/moesin ; Phosphorylation ; Na+/H+-exchange 1 ; T cells
- 刊名：Steroids
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：29-36
- 全文大小：780 K
文摘
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GCs stimulate a rapid non-genomic cp-ERM response in cells within 5 min.
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RU486 antagonized the GC-induced rapid decrease in NHE1 activity.
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RU486 antagonized the GC-arrested PHA-stimulated T cells at G0/G1 phase.
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RU486 had no effect on the rapid increase in cp-ERM and it persisted for 24 h.
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RU486 antagonized at NHE1 containing plasma membrane sites but not at cp-ERM sites.