Microdialysis combined with liquid chromatography-tandem mass spectrometry for the determination of nimodipine in the guinea pig hippocampus
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- 作者：Chen Wanga ; Xiaojing Lua ; Liqin Lia ; liliqinpla@163.com" class="auth_mail" title="E-mail the corresponding author ; Ruihua Zhanga ; Tong shia ; Shu Lib ; judy_lishu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microdialysis ; LC&ndash ; MS/MS ; Nimodipine ; Hippocampus ; Pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：1017-1018
- 期：Complete
- 页码：226-232
- 全文大小：1068 K
文摘
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The pharmacokinetic behavior of nimodipine in guinea pig hippocampus was determined.
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Microdialysis technique was used for sample collection.
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A rapid and sensitive LC–MS/MS method was developed and validated.
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The method was sensitive with a LLOQ of 0.2 ng/ml for nimodipine.