We investigated the relationship between atypical E2F transcription factor, E2F7 and clinical prognosis of human glioma.
Indeed, we demonstrated E2F7 predicts tumor progression and poor prognosis in glioma.
We demonstrated that elevated E2F7 expression in glioma is proportional to expression of CDK1.
Over-expression of CDK1 was found to promote oncogenesis and progression of human glioma.
These results support a role for the E2F7 gene in glioma and uncover diagnostic and therapeutic expectations.