Proteomic analysis reveals differentially secreted proteins in the urine from patients with clear cell renal cell carcinoma
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- 作者：Vanessa Sandim ; Ph.D.a ; b ; c ; d ; Denise de Abreu Pereira ; Ph.D.a ; b ; c ; e ; Dá ; rio Eluan Kalume ; Ph.D.a ; f ; Ana Lucia Oliveira-Carvalho ; B.Sc.a ; b ; Antonio Augusto Ornellas ; Ph.D.g ; h ; Marcia Regina Soares ; Ph.D.i ; Gilda Alves ; Ph.D.c ; d ; e ; 1 ; galvesbrown@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Russolina Benedeta Zingali ; Ph.D.a ; b ; lzingali@bioqmed.ufrj.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Renal cell carcinoma ; Urine ; Label-free MSE ; Quantitative proteomics ; Secreted proteins
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：34
- 期：1
- 页码：5.e11-5.e25
- 全文大小：2150 K
文摘
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Different mass spectrometric approaches identified 354 proteins in the urine from patients with ccRCC.
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KNG1, UMOD, APOD, polyubiquitin, and CD59 were down secreted in the urine from patients with ccRCC.
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APOA1, fibrinogen, and haptoglobin were up secreted in urine from patients with ccRCC.
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Up-secreted and down-secreted proteins were correlated to the progression of the disease.