Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain
详细信息 查看全文
- 作者：Ling-Jun Zhao ; Paul M. Loewenstein ; Maurice Green ; green@slu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：E1A 1-80 ; 243R ; NuA4 ; TRRAP ; DMAP1 ; RUVBL1 ; RUVBL2 ; Tip60
- 刊名：Virology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：499
- 期：Complete
- 页码：178-184
- 全文大小：1005 K
文摘
- •
E1A 243R interacts with DMAP1, RUVBL1, RUVBL2, TRRAP, p400, and MYC.
- •
These cellular proteins, except MYC, are part of the NuA4/Tip60 complex.
- •
E1A 243R interaction with the NuA4/Tip60 complex promotes its association with MYC.
- •
The NuA4/Tip60 complex may be critical for cellular transformation by MYC and E1A.