Association of increased S100B, S100A6 and S100P in serum levels with acute coronary syndrome and also with the severity of myocardial infarction in cardiac tissue of rat models with ischemia–reperfusion injury

详细信息    查看全文

• 作者：Xue Ying Cai^a ; ¹ ; Lin Lu^a ; ^b ; ¹ ; Ya Nan Wang^b ; Cao Jin^a ; Rui Yan Zhang^a ; Qi Zhang^a ; Qiu Jing Chen^b ; Wei Feng Shen^a ; ^b ; ^{rjshenweifeng@yahoo.com.cn"" rel=""nofollow}
• 关键词：S100B ; S100A6 ; S100P ; Receptor for advanced glycation end products ; Acute coronary syndrome
• 刊名：Atherosclerosis
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：217
• 期：2
• 页码：536-542
• 全文大小：1066 K

文摘

Objective

We aim to check if serum levels of receptor for advanced glycation endproduct (RAGE) ligands S100B, S100A6 and S100P were related to myocardial injury in acute coronary syndrome (ACS).

Methods

Serum levels of S100B, S100A6, S100P, and soluble RAGE (sRAGE) were analyzed in 882 patients. Based upon clinical and laboratory findings, they were assigned into control (n = 251), stable angina (n = 211), and ACS (n = 420). To verify clinical data of ACS, forty Sprague-Dawley rats were subjected to cardiac ischemia–reperfusion (I/R) injury by occluding proximal (large infarct size; n = 20) or distal (small infarct size; n = 20) left anterior descending coronary artery, and another 20 rats were in sham-operation group. The expressions of S100B, S100A6, S100P and RAGE in the myocardium were analyzed.

Results

Serum levels of S100B, S100A6 and S100P were higher in ACS group than in stable angina and control groups, and sRAGE levels were higher in ACS patients versus controls (all p < 0.01). S100B and S100P levels correlated significantly with CK-MB and troponin I levels in ACS group (all p < 0.05). In multivariable regression analysis, S100B, S100A6, S100P and conventional risk factors were independently associated with ACS. In animal models, the expressions of S100B, S100A6 and S100P were closely related to infarct size (all p < 0.05).

Conclusion

This study indicates that serum levels of S100B, S100A6 and S100P are associated with ACS, and serum levels and myocardial expression of these proteins are related to infarct size.