High-affinity interaction between interleukin-11 and S100P protein
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- 作者：Alexei S. Kazakova ; Andrei S. Sokolova ; Victoria A. Rastryginaa ; Valery V. Solovyevb ; Ramis G. Ismailova ; Roman V. Mikhailovc ; Andrei B. Ulitinb ; Andrey R. Yakovenkod ; Tajib A. Mirzabekovc ; e ; Eugene A. Permyakova ; Sergei E. Permyakova ; permyakov.s@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cancer ; Interleukin ; S100 protein ; Protein&ndash ; protein interaction ; STAT3
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：25 December 2015
- 年：2015
- 卷：468
- 期：4
- 页码：733-738
- 全文大小：840 K
文摘
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Interleukin-11 (IL-11) selectively interacts with Ca2+-bound S100P protein.
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IL-11 has at least two S100P-binding sites.
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Affinity of IL-11 to S100P is 5–13-fold lower compared to that for sIL-11Rα.
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S100P does not affect IL-11-induced STAT3 activation in modified HEK293 cells.
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This interaction is relevant to the development of drugs targeting IL-11 signaling.