Role of α4-containing GABA_A receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period

详细信息    查看全文

• 作者：Hui Shen^a ; ^b ; Nicole Sabaliauskas^b ; ^c ; Lie Yang^b ; Chiye Aoki^c ; Sheryl S. Smith^b ; ^{Sheryl.smith@downstate.edu}
• 关键词：GABA-A receptor ; Alpha-4 ; Alpha-5 ; Delta ; Hippocampus ; Puberty ; Spatial learning ; Long-term potentiation
• 刊名：Brain Research
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：1654
• 期：part_PB
• 页码：116-122
• 全文大小：592 K
• 卷排序：1654

文摘

Pubertal impairment of synaptic plasticity is restored by α4 knock-out. Pubertal impairment of synaptic plasticity is not restored by α5 blockade. Pubertal impairment of spatial learning is restored by α4 knock-out. Pubertal α4βδ GABARs impair CNS plasticity and learning.