Forced swimming sabotages the morphological and synaptic maturation of newborn granule neurons and triggers a unique pro-inflammatory milieu in the hippocampus
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- 作者：Marí ; a Llorens-Martí ; n ; m.llorens@csic.es" class="auth_mail" title="E-mail the corresponding author ; Jeró ; nimo Jurado-Arjona ; Marta Boló ; s ; Noemí ; Pallas-Bazarra ; Jesú ; s Á ; vila ; javila@cbm.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adult hippocampal neurogenesis ; Retrovirus ; Acute stress ; Forced swimming ; Inflammation ; Microglia
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：242-254
- 全文大小：3746 K
文摘
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Forced swimming impedes morphological and functional maturation of newborn neurons.
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Forced swimming induces the functional and morphological activation of microglia.
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Forced swimming triggers an intriguing shift in the hippocampal inflammatory milieu.
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Molecules altered by the Porsolt test are dysregulated in patients with depression.