Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development
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- 作者：Sadanori Watanabe1 ; sadanori.watanabe@bio.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Go Shioi2 ; Yasuhide Furuta2 ; 3 ; Gohta Goshima1 ; goshima@bio.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：augmin ; γ-tubulin complex ; early mouse development ; MTOC clustering ; spindle
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：15
- 期：1
- 页码：54-60
- 全文大小：2666 K
文摘
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An augmin knockout (KO) mouse is used to examine microtubule nucleation
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Augmin is essential for embryonic cell division during mouse development
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Live imaging of synchronized embryos reveals augmin-dependent clustering of MTOCs
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Intra-spindle MT assembly, but not augmin itself, is required for MTOC clustering