Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor

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• 作者：Masaji Sakaguchi¹ ; Shiho Fujisaka¹ ; Weikang Cai¹ ; Jonathon N. Winnay¹ ; Masahiro Konishi¹ ; Brian T. O'Neill¹ ; ³ ; Mengyao Li¹ ; Rubé ; n Garcí ; a-Martí ; n¹ ; Hirokazu Takahashi¹ ; Jiang Hu² ; Rohit N. Kulkarni² ; C. Ronald Kahn¹ ; ⁴ ; ^{c.ronald.kahn@joslin.harvard.edu}
• 关键词：insulin action ; adipogenesis ; adipocyte regeneration ; insulin receptor knockout ; insulin resistance ; lineage tracing ; β cell proliferation ; fatty liver ; brown adipocyte ; leptin
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：448-462
• 全文大小：7713 K
• 卷排序：25

文摘

Mature adipose tissue depends on insulin signaling for maintenance and survival Acute loss of insulin signaling in fat results in a reversible metabolic syndrome Fat loss stimulates preadipocyte proliferation and regeneration of white/brown fat Inducible lipodystrophy stimulates rapid proliferation of pancreatic β cells