Ti-Salan catalyzed asymmetric sulfoxidation of pyridylmethylthiobenzimidazoles to optically pure proton pump inhibitors
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- 作者：Evgenii P. Talsia ; b ; Konstantin P. Bryliakova ; b ; bryliako@catalysis.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：Asymmetric oxidation ; Esomeprazole ; Hydrogen peroxide ; Isoinversion ; Mechanism ; Titanium ; Salan
- 刊名：Catalysis Today
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：279
- 期：part_P1
- 页码：84-89
- 全文大小：667 K
文摘
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The new environmentally benign process for the synthesis of esomeperazole is reported.
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The first asymmetric sulfoxidation of pyridylmethylthiobenzimidazoles on Ti-salan complexes.
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The temperature dependence of enantioselectivity demonstrates isoinversion behavior.
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The structure-reactivity relationships for the catalysts and the oxidation mechanism are discussed.