Effects of vitamin E on lead-induced impairments in hippocampal synaptic plasticity
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- 作者：Iraj Salehi ; Ruhollah Karamian ; ruhollahkaramian@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Alireza Komaki ; alirezakomaki@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Komaki@umsha.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Lida Tahmasebi ; Masoumeh Taheri ; Masoumeh Nazari ; Siamak Shahidi ; Abdolrahman Sarihi
- 关键词：Lead acetate ; Hippocampus ; Vitamin E ; Dentate gyrus ; Long-term potentiation ; Antioxidants ; Rat
- 刊名：Brain Research
- 出版年：2015
- 出版时间：10 December 2015
- 年：2015
- 卷：1629
- 期：Complete
- 页码：270-281
- 全文大小：906 K
文摘
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Oxidative stress induced by chronic Lead (Pb) may contribute to cognitive deficits
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Pb exposure is associated with an impairment of synaptic plasticity in animal models.
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Vitamin E has many beneficial health effects, such as antioxidant properties.
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Vitamin E prevents oxidative damage and cognitive deficit caused by oxidative stress.
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Vitamin E reverses Pb-induced deficits in hippocampal synaptic plasticity.