Interactive effects of AM251 and baclofen on synaptic plasticity in the rat dentate gyrus
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- 作者：Masoumeh Nazari ; Alireza Komaki ; alirezakomaki@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Komaki@umsha.ac.ir" class="auth_mail" title="E-mail the corresponding author ; ; Iraj Salehi ; Abdolrahman Sarihi ; Siamak Shahidi ; Hamidreza Komaki ; Ahmad Ganji
- 关键词：Cannabinoid ; GABAergic ; AM251 ; GABAB ; Baclofen ; Long-term potentiation
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：1651
- 期：Complete
- 页码：53-60
- 全文大小：823 K
文摘
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Cannabinoid receptors (CB1) participate in multiple type of synaptic plasticity.
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CB1 receptor stimulation affects the release of GABA.
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GABAB receptors play a substantial role in long-term potentiation (LTP).
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CB1 antagonists can alter GABA release, which in turn enhances LTP.
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GABAB and CB1 receptors may have a functional interaction in signaling pathway in LTP.