Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents

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• 作者：Minjian Huang^a ; Zixin Deng^a ; ^b ; Jian Tian^a ; ^c ; ^{Jian.Tian@whu.edu.cn} ; Tiangang Liu^a ; ^b ; ^{liutg@whu.edu.cn}
• 关键词：Salinomycin ; Anticancer activity ; CuAAC reaction ; Breast cancer
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：900-908
• 全文大小：956 K
• 卷排序：127

文摘

A series of new salinomcyin triazole analogues were synthesized through convenient CuAAC reactions. Salinomcyin triazole derivatives modified at the C20 hydroxyl group displayed potent antitumour activities. Salinomycin triazole dimers were 3.27–4.97 times more toxic than salinomycin against breast cancer cell line MCF-7.