Samarium diiodide mediated intramolecular cyclisation of mixed enone–enoate systems: a simple preparation of spirocyclic ethers

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• 作者：Junxiu Meng^a ; ^b ; Mark E. Light^a ; Jeremy D. Kilburn^a ; ^{j.kilburn@qmul.ac.uk} ; Sally Dixon^a ; ^{sd5@soton.ac.uk}
• 关键词：Samarium(II) diiodide ; Reductive cyclisation ; Michael addition ; Spirocycle ; Chelation control
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：23 February 2011
• 年：2011
• 卷：52
• 期：8
• 页码：928-931
• 全文大小：454 K

文摘

Samarium(II) diiodide mediated intramolecular cyclisation of mixed enone–enoate substrates in THF/MeOH is described. Spirocyclic ethers are obtained, and the stereodefined preparation of 1-oxaspiro[4.4]nonan-7-one products is included.