Clinical impact of prolonged diagnosis to treatment interval (DTI) among patients with oropharyngeal squamous cell carcinoma

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• 作者：Sonam Sharma^a ; ^{sonam.sharma@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; Justin Bekelman^a ; Alexander Lin^a ; J. Nicholas Lukens^a ; Benjamin R. Roman^c ; Nandita Mitra^b ; Samuel Swisher-McClure^a
• 关键词：Oropharyngeal cancer ; National Cancer Data Base ; Treatment delays
• 刊名：Oral Oncology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：56
• 期：Complete
• 页码：17-24
• 全文大小：640 K

文摘

We examined practice patterns using the National Cancer Data Base (NCDB) to determine risk factors for prolonged diagnosis to treatment interval (DTI) and survival outcomes in patients receiving chemoradiation for oropharyngeal squamous cell carcinoma (OPSCC).

Methods and materials

We identified 6606 NCDB patients with Stage III–IV OPSCC receiving chemoradiation from 2003 to 2006. We determined risk factors for prolonged DTI (>30 days) using univariate and multivariable logistic regression models. We examined overall survival (OS) using Kaplan Meier and multivariable Cox proportional hazards models.

Results

3586 (54.3%) patients had prolonged DTI. Race, IMRT, insurance status, and high volume facilities were significant risk factors for prolonged DTI. Patients with prolonged DTI had inferior OS compared to DTI ⩽ 30 days (Hazard Ratio (HR) = 1.12, 95% CI 1.04–1.20, p = 0.005). For every week increase in DTI there was a 2.2% (95% CI 1.1–3.3%, p < 0.001) increase in risk of death. Patients receiving IMRT, treatment at academic, or high-volume facilities were more likely to experience prolonged DTI (High vs. Low volume: 61.5% vs. 51.8%, adjusted OR 1.38, 95% CI 1.21–1.58; Academic vs. Community: 59.5% vs. 50.6%, adjusted OR 1.26, 95% CI 1.13–1.42; non-IMRT vs. IMRT: 53.4% vs. 56.5%; adjusted OR 1.17, 95% CI 1.04–1.31).

Conclusions

Our results suggest that prolonged DTI has a significant impact on survival outcomes. We observed disparities in DTI by socioeconomic factors. However, facility level factors such as academic affiliation, high volume, and IMRT also increased risk of DTI. These findings should be considered in developing efficient pathways to mitigate adverse effects of prolonged DTI.