Comparison of surgical outcomes between papillary thyroid cancer patients treated with the聽Harmonic ACE scalpel and LigaSure Precise instrument during conventional thyroidectomy: a聽single-blind prospective randomized controlled聽trial

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• 作者：Hee Yong Kwak ; MD^a ; Byung Joo Chae ; MD^a ; Yong-Gyu Park ; PhD^b ; Sang Hoon Kim ; MD^a ; Eun Young Chang ; MD^a ; Eun Jin Kim ; MD^a ; Byung Joo Song ; MD^a ; Sang Seol Jung ; MD^a ; Ja Seong Bae ; MD^a ; ^{drbae@catholic.ac.kr" class="auth_mail}
• 关键词：Clinical trials ; Thyroid cancer ; Thyroidectomy ; Hemostasis ; Harmonic scalpel ; LigaSure
• 刊名：Journal of Surgical Research
• 出版年：April, 2014
• 年：2014
• 卷：187
• 期：2
• 页码：484-489
• 全文大小：373 K

文摘

Background

The aim of this study was to evaluate the safety and efficacy of thyroidectomy using the Harmonic ACE scalpel (HS) or the LigaSure Precise (LS) instrument in conventional thyroidectomy.

Materials and methods

A prospective, randomized controlled trial was performed. Between August 2011 and June 2012, 832 patients who required thyroidectomy for papillary thyroid cancer were randomized into groups treated with either the HS or the LS instrument. Operative time and surgical morbidities were analyzed.

Results

A total of 320 patients (HS group, N聽=聽164; LS instrument group, N聽=聽156) were randomized for analysis according to the intention-to-treat principle. There were no statistically significant differences in the operative times (HS group versus LS instrument group: 71.93聽卤聽18.26 versus 75.15聽卤聽20.13; P聽=聽0.423), postoperative transient hypoparathyroidism (13.4% versus 14.1%; P聽=聽0.858), and permanent recurrent laryngeal nerve injuries between the two groups.

Conclusions

In this study, both hemostatic devices were safe and effective in terms of postoperative results and complications without any differences.