Small-angle neutron scattering studies of microenvironmental and structural changes of Pluronic micelles upon encapsulation of paclitaxel

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• 作者：Khalilalrahman Dehvari^a ; ^{Dehvarikh@gmail.com} ; ^{Dehvari@saturn.yzu.edu.tw} ; Kuen-Song Lin^a ; ^{kslin@saturn.yzu.edu.tw} ; Boualem Hammouda^b ; ^{boualem.hammouda@nist.gov}
• 关键词：Pluronic prodrug ; SANS ; Paclitaxel ; Nanocarrier ; Drug delivery system
• 刊名：Journal of the Taiwan Institute of Chemical Engineers
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：405-413
• 全文大小：2240 K
• 卷排序：71

文摘

Small angle neutron scattering was used to probe changes in the core-shell structure of Pluronic P123 micelles as a function of increasing paclitaxel and Pluronic concentration. Complementary cryogenic- transmission electron microscopy measurements revealed that the increasing PTX concentration associated with the appearance of the larger particles of the drug surrounded by Pluronic micelles. At higher Pluronic concentration and a constant PTX concentration, the dimensions of micelles increased due to the altered hydrophobic environment in the core of micelles.