Perioperative high-dose-rate brachytherapy in soft tissue sarcomas of the extremity and superficial trunk in adults: Initial results of a pilot study

详细信息    查看全文

• 作者：Rafael Martí ; nez-Monge ; Mikel San Juliá ; n ; Santiago Amillo ; Mauricio Cambeiro ; Leire Arbea ; Jeanette Valero ; Marí ; a Gonzá ; lez-Cao and Salvador Martí ; n-Algarra
• 刊名：Brachytherapy
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：4
• 期：4
• 页码：264-270
• 全文大小：152 K

文摘

Purpose

This study was undertaken to determine the feasibility of perioperative high-dose-rate brachytherapy (PHDRB) as an alternative to standard low-dose-rate brachytherapy in adult patients with soft tissue sarcomas.

Methods and materials

Twenty-five adult patients with soft tissue sarcomas of the extremities or the superficial trunk were treated with surgical resection and PHDRB (16, 24, or 32 Gy) for negative, close/microscopically positive, or grossly involved surgical resection margins, respectively. External beam radiation therapy (45 Gy) was added postoperatively. Adjuvant chemotherapy with ifosfamide and doxorubicin was given to patients with high-grade tumors.

Results

Resection margins were negative in 6 patients (24.0 % ), close/microscopically positive in 18 (72.0 % ), and grossly involved in 1 (4.0 % ). One patient (4.0 % ) with wound dehiscence needed reoperation. Three patients failed in the anatomical region treated, but relapse sites were not adjacent to the area treated with PHDRB. After a median followup of 23.2 months (range 2.8–48.0), the 4-year local and regional control rates were 100 % and 80.5 % , respectively. Four-year overall survival was 78.2 % .

Conclusions

Locoregional control and survival results are encouraging for this high-risk patient population. PHDRB results seem to be similar to those obtained with low-dose-rate brachytherapy.