NOD2/CARD15 polymorphisms impair innate immunity and increase susceptibility to gastric cancer in an Italian population
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- 作者：Silvia Angeletti ; Sara Galluzzo ; Daniele Santini ; Annamaria Ruzzo ; Bruno Vincenzi ; Elisabetta Ferraro ; Chiara Spoto ; Giulia Lorino ; Nicoletta Graziano ; Alice Calvieri ; Mauro Magnani ; Francesco Grazian
- 关键词：Cancer risk ; Gastric cancer ; Genetic susceptibility ; Innate immunity ; CARD15/NOD2 polymorphisms
- 刊名：Human Immunology
- 出版年：2009
- 出版时间：September 2009
- 年：2009
- 卷：70
- 期：9
- 页码：729-732
- 全文大小：241 K
文摘
In the present case–control study we investigated the potential role of CARD15 R702W, G908R, and 1007fs polymorphisms in Italian gastric cancer patients. The study population consisted of 170 gastric cancer patients and 156 controls. Unconditional regression (odds ratios and 95 % confidence interval) was used to investigate the association of the studied polymorphisms with gastric cancer. Higher allele frequencies of R702W and 1007fs polymorphisms were observed in patients with gastric cancer compared with controls (8.53 vs 2.3 and 9.4 vs 0.7, respectively). CARD15 R702W and 1007fs polymorphisms were significantly correlated with gastric cancer incidence (p < 0.0001, p < 0.0001, respectively). No correlation was found upon analyzing the G908R single nucleotide polymorphism (SNP). Our study reports an increased susceptibility to gastric cancer in Italian populations when R702W and 1007fs polymorphisms in the coding region of CARD15 are present. The interaction between NOD-induced proinflammatory cytokines on gastric mucosa and environmental carcinogens could represent one of the mechanisms by which CARD15 polymorphisms increase the susceptibility to gastric cancer. Meta-analyses of these SNPs and further analyses of additional polymorphisms/haplotypes in NOD genes will help determine their role in carcinogenesis.