In diabetes patients, total health care costs are significantly higher for opioid users.
Costs per 6 months increased linearly with increasing daily and total opioid doses.
A novel measure combining mean daily and total dose best discriminated higher costs.
Total costs >$8,000 greater for 50–99 mg mean daily opioid dose and >900 mg total dose.
Total costs also >$8,000 greater for ≥100 mg mean daily dose and >300 mg total dose.