Expression of Fibroblast Activating Protein and Correlation with Histological Grade, Mitotic Index and Ki67 Expression in Canine Mast Cell Tumours

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• 作者：A. Giuliano^&lowast ; ; ^{ag847@cam.ac.uk} ; R. dos Santos Horta^&dagger ; ; F. Constantino-Casas^&lowast ; ; T. Hoather^&lowast ; ; J. Dobson^&lowast ;
• 关键词：dog ; fibroblast activating protein ; mast cell tumour
• 刊名：Journal of Comparative Pathology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：156
• 期：1
• 页码：14-20
• 全文大小：1329 K
• 卷排序：156

文摘

Fibroblast activating protein (FAP) is a membrane serine protease expressed by activated fibroblasts, particularly tumour associated fibroblasts (TAFs). FAP expression has not been reported in canine mast cell tumours (MCTs). The objective of this study was to evaluate the expression of FAP in TAFs and its correlation with histological grade, mitotic index and Ki67 expression in canine MCTs. FAP expression was evaluated by immunohistochemistry (IHC) in 30 canine MCTs. Twenty-eight (90%) of the MCTs expressed FAP in the stroma, 16 cases showed low to intermediate FAP score and 14 cases had a high FAP score. FAP was correlated positively with both Patnaik (P = 0.007) and Kiupel (P = 0.008) grading systems, mitotic index (P = 0.0008) and Ki67 expression (P = 0.009). High stromal FAP expression could be a potential negative prognostic factor in canine MCTs.