Zinc-Induced Polymerization of Killer-Cell Ig-like Receptor into Filaments Promotes Its Inhibitory Function at Cytotoxic Immunological Synapses
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- 作者：Santosh Kumar1 ; Sumati Rajagopalan1 ; Pabak Sarkar2 ; David W. Dorward3 ; Mary E. Peterson1 ; Hsien-Shun Liao4 ; 8 ; Christelle Guillermier5 ; 6 ; 7 ; Matthew L. Steinhauser5 ; 6 ; 7 ; Steven S. Vogel2 ; Eric O. Long1 ; elong@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：filament ; inhibition ; natural killer cell ; signaling ; zinc
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：62
- 期：1
- 页码：21-33
- 全文大小：4898 K
文摘
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Inhibitory killer-cell Ig-like receptor (KIR) polymerizes in the presence of zinc
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Zinc induces KIR assembly into filaments at the plasma membrane of NK cells
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KIR mutants that fail to polymerize but still bind HLA-C lack inhibitory function
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KIR polymerizes into filaments at functional inhibitory NK cell immunological synapses