γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5-component cascades

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• 作者：H. Ali Dondas^a ; ^b ; Aiden Hempshall^a ; Sarah Narramore^a ; Colin Kilner^a ; Colin W.G. Fishwick^a ; ^{c.w.g.fishwick@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Ronald Grigg^a ; ^{r.grigg@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：γ-Carbolines ; Palladium catalysed ; HDAC inhibitor ; Uridine allene ; Cascade chemistry
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：10 March 2016
• 年：2016
• 卷：72
• 期：10
• 页码：1316-1329
• 全文大小：1844 K

文摘

γ-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce γ-carboline based HDAC inhibitors.