Successful treatment of paroxysmal tonic spasms with topiramate in a patient with neuromyelitis optica
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- 作者：Shin Iida ; Masataka Nakamura ; Reika Wate ; Satoshi Kaneko ; kanekosa@takii.kmu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hirofumi Kusaka
- 关键词：MV ; mechanical ventilation ; PE ; plasma exchange ; PTS ; paroxysmal tonic spasms
- 刊名：Multiple Sclerosis and Related Disorders
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：4
- 期：5
- 页码：457-459
- 全文大小：384 K
文摘
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Carbamazepine was initially effective against paroxysmal tonic spasms (PTS).
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However, carbamazepine caused drug eruption.
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Then topiramate was started, and PTS promptly disappeared.
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Carbamazepine and topiramate have a common action to block sodium channels.
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This action may have contributed to inhibit PTS.