Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling

详细信息    查看全文

• 作者：Shoichiro Kokabu ; Tsuyoshi Sato ; Satoshi Ohte ; Yuichiro Enoki ; Masahiko Okubo ; Naoki Hayashi ; Junya Nojima ; Sho Tsukamoto ; Yosuke Fukushima ; Yasuaki Sakata ; Takenobu Katagiri ; Vicki Rosen ; Tetsuya Yoda
• 关键词：TLE ; transducing-like enhancer of split ; ALP ; alkaline phosphatase ; BMP ; bone morphogenetic protein ; OC ; Osteocalcin ; PPAR纬 ; proliferator-activated receptor 纬 ; C/EBP ; CCAAT/enhancer-binding protein ; BMSC ; bone marrow stromal cell
• 刊名：FEBS Letters
• 出版年：14 February, 2014
• 年：2014
• 卷：588
• 期：4
• 页码：614-619
• 全文大小：742 K

文摘

Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. Taken together, our data suggest that induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation.