Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice

详细信息    查看全文

• 作者：Rieko Takanabe-Mori ; Koh Ono ; Naoya Sowa ; Hiromichi Wada ; Tomohide Takaya ; Takahiro Horie ; Noriko Satoh-Asahara ; Akira Shimatsu ; Masatoshi Fujita ; Tatsuya Sawamura ; Koji Hasegawa
• 关键词：Oxidized LDL ; Obesity ; Inflammation ; Mesenteric fat
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2010
• 出版时间：30 July 2010
• 年：2010
• 卷：398
• 期：3
• 页码：576-580
• 全文大小：378 K

文摘

Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is a receptor for oxidized LDL, and is strongly expressed in endothelial cells at an early stage of atherosclerosis. LOX-1 expression in adipocytes is induced by PPARγ (ligands and appears to be involved in adipocyte cholesterol metabolism. However, the role of adipose tissue LOX-1 in high-fat diet-induced obesity is unknown. We found that mRNA levels of adipose tissue LOX-1 were markedly increased in obese mice fed a high-fat diet (HFD) compared with those fed normal chow. The levels were closely correlated with those of a proinflammatory cytokine, monocyte chemoattractant protein-1 (MCP-1). Then, LOX-1 knockout (LOX-1-KO) and wild-type (WT) mice were fed HFD for 16 weeks. HFD feeding increased the body and mesenteric fat weights similarly in WT and LOX-1-KO mice. HFD-induced expressions of proinflammatory cytokines such as MCP-1, MIP-1α, and IL-6 were significantly less in LOX-1-KO than WT mice. Thus, LOX-1 is required for the HFD-induced expression of proinflammatory cytokines in the adipose tissue of obese mice.