The impact of l-dopa on attentional impairments in a rat model of Parkinson’s disease
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- 作者：Elizabeth S. Smith ; Gwendolyn A. Hardy ; Timothy Schallert ; Hongjoo J. Lee ; leehj@austin.utexas.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIM ; abnormal involuntary movement ; LIDs ; l-dopa induced dyskinesias ; MPTP ; l-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; NHS ; normal horse serum ; PD ; Parkinson&rsquo ; s disease ; PFA ; Paraformaldehyde ; PFC ; prefrontal cortex ; TH ; tyrosine hydroxylase ; VTA ; ventral tegmental area
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：19 November 2016
- 年：2016
- 卷：337
- 期：Complete
- 页码：295-305
- 全文大小：748 K
文摘
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l-Dopa dose necessary to recover motor function can also successfully restore disengagement behavior in the short term.
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l-Dopa dose that recovers disengagement behavior and motor function does not improve selective and sustained attention.
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l-Dopa therapy may not be sufficient for treating all types of attentional dysfunction occurring in Parkinson’s disease.