Is there a natural limit of the transformation rate of oral leukoplakia?

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• 作者：Scheifele ; Christian ; Reichart ; Peter A.
• 关键词：Oral leukoplakia ; Squamous cell carcinoma ; Neoplastic cell transformation ; Logistic models ; Risk assessment
• 刊名：Oral Oncology
• 出版年：2003
• 出版时间：July, 2003
• 年：2003
• 卷：39
• 期：5
• 页码：470-475
• 全文大小：213 K

文摘

Recent reviews described a cumulative risk of 0–38 % of oral leukoplakias (OL) to transform into oral squamous cell carcinoma (OSCC). The annual transformation rate (ATR) of OL into OSCC amounted up to 6.3 % . To elucidate epidemiological consequences of varying ATR. Variations of the prevalence (1–2 % ) and ATR (0.5–4 % ) of OL were used to compute the proportional incidences of OSCC developing in OL. These were compared to the actual incidences of OSCC excerpted from European cancer registries. A ratio <50 % of predicted to actual incidence overall indicated a plausible ATR. With an ATR≥3 % , the predicted incidences of OSCC would exceed the reported incidences in all countries. With an ATR≤1 % , the ratio of OSCC developed in OL to OSCC overall would be always lower than 50 % . Based on present data, it was concluded that the ATR of OL into OSCC should not exceed 1 % .