- 作者：Silvia Carvalho Fern ; o ; Thomas Beblo ; Nicole Schlosser ; Kirsten Terfehr ; Oliver Tobias Wolf ; Christian Otte ; Bernd L枚we ; Carsten Spitzer ; Martin Driessen ; Katja Wingenfeld
- 关键词：Response inhibition ; Go/no-go ; Borderline personality disorder ; Cortisol ; HPA axis
- 刊名：Psychoneuroendocrinology
- 出版年：November, 2013
- 年：2013
- 卷：38
- 期：11
- 页码：2780-2788
- 全文大小：573 K
Summary
Introduction
Growing evidence suggests inhibition dysfunctions in borderline personality disorder (BPD). Moreover, abnormalities in hypothalamic-pituitary-adrenal (HPA) axis functioning have also been found in BPD patients. In healthy individuals, response inhibition has been sensitive to acute stress, and previous research indicates that effects mediated by the HPA axis become particularly apparent when emotional stimuli are processed. This study aimed to explore the influence of acute hydrocortisone administration on response inhibition of emotional stimuli in BPD patients compared to healthy control participants.Methods
After a single administration of 10 mg hydrocortisone or placebo, 32 female BPD patients and 32 healthy female participants performed an adapted emotional go/no-go paradigm to assess response inhibition for emotional face stimuli in a cross-over study.
Results
Acute cortisol elevations decreased the reaction times to target stimuli in both BPD patients and healthy controls. Patients and controls did not differ in task performance; however, BPD patients with comorbid posttraumatic stress disorder (PTSD) displayed longer reaction times than patients without PTSD. In contrast, the occurrence of comorbid eating disorder had no significant impact on go/no-go performance. No significant interaction effect between the treatment condition and the emotional valence of the face stimuli was found.
Conclusions
Acute hydrocortisone administration enhances response inhibition of face stimuli in BPD patients and healthy controls, regardless of their emotional valence. Our results agree with the suggestion that moderate cortisol enhancement increases the inhibition of task-irrelevant distracters.