Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

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• 作者：Anja Schneider ; Walter Schulz-Schaeffer ; Tobias Hartmann ; Jö ; rg B. Schulz and Mikael Simons
• 刊名：Neurobiology of Disease
• 出版年：2006
• 出版时间：September 2006
• 年：2006
• 卷：23
• 期：3
• 页码：573-577
• 全文大小：254 K

文摘

A key event in the pathogenesis of Alzheimer's disease is the conversion of soluble amyloid Aβ-peptide into toxic aggregates. Here, we studied the effect of cholesterol depletion on the formation of insoluble Aβ. We found that reduction of neuronal cholesterol by 25 % reduced the neuronal formation of insoluble Aβ without affecting the secretion of soluble Aβ. Moreover, we demonstrate that Aβ-oligomers from Alzheimer's disease brains associate with a detergent-resistant membrane fraction in a cholesterol-dependent manner. These results suggest a key role for cholesterol in aggregation of Aβ.