Cores of Schrenk spruce from seven sites of eastern Tien Shan were used to develop a regional tree-ring chronology to extend the climate record. We developed an August–July Standardized Precipitation Evapotranspiration Index (SPEI) reconstruction that spans AD 1725–2013 based on the regional tree-ring chronology. The reconstruction model accounts for 45.3% of the SPEI variance from 1959 to 2013. The SPEI reconstruction agrees reasonably well with the dry and wet periods previously estimated from tree rings in northern Xinjiang. The correlation analysis revealed that temperature plays an important role in regional drought variability, and some extreme wet years also coincide with the volcanic eruptions.